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539 Results from several Phase III clinical trials (ORION-9/10/11, NCT03397121, NCT03399370, and NCT03400800) have shown that subcutaneous injections of inclisiran every 6 months considerably reduce LDL-C levels by 4852%, demonstrating sustained efficacy and good tolerability

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S10B and S10C), as well as a significant reduction in IBA1 positive cells as compared to the AL-fed mice (Fig